The predicted impact and cost-effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome.

Yoon-Jung KangJames KillenMichael CaruanaKate SimmsNatalie TaylorIan M FraylingTristan SnowsillNicola HuxleyVeerle Mh CoupeSuzanne HughesVictoria FreemanAlex BoussioutasAlison H TrainerRobyn L WardGillian MitchellFinlay A MacraeKaren Canfell

Published in: The Medical journal of Australia (2019)

Universal tumour testing strategies for guiding germline genetic testing of people with incident CRC for LS in Australia are likely to be cost-effective compared with no testing. Universal germline gene panel testing would not currently be cost-effective.

Keyphrases

dna repair
genome wide
gene expression
dna methylation
copy number
case report
oxidative stress
dna damage