Plasma proteome profiling of healthy subjects undergoing bed rest reveals unloading-dependent changes linked to muscle atrophy.
Marta MurgiaLorenza BroccaElena MontiMartino V FranchiMaximilian ZwiebelSophia SteigerwaldEmiliana GiacomelloRoberta SartoriSandra ZampieriGiovanni CapovillaMladen GaspariniGianni BioloMarco SandriMatthias MannMarco V NariciPublished in: Journal of cachexia, sarcopenia and muscle (2022)
Our findings highlight a combination or proteomic changes that can be explored as potential biomarkers of muscle atrophy occurring under different conditions. The panel of significant proteomic differences distinguishing atrophy-prone and atrophy-resistant subjects after 10 days of bed rest need to be tested in a larger cohort to validate their potential to predict inactivity-triggered muscle loss in humans.
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