Discovering interactions in polypharmacy: Impact of metamizole on the metabolism of quetiapine.

Fabian WatermeyerArnim Johannes GaeblerIrene NeunerEkkehard HaenChristoph HiemkeGeorgios SchoretsanitisMichael Paulzen

Published in: British journal of clinical pharmacology (2024)

The combination of metamizole and quetiapine leads to significantly lower drug concentrations of quetiapine, probably via an induction of CYP3A4. Clinicians must consider the risk of adverse drug reactions, especially treatment failure under quetiapine when adding metamizole.

Keyphrases

adverse drug
electronic health record
emergency department
drug induced
combination therapy