Genetics impact risk of Alzheimer's disease through mechanisms modulating structural brain morphology in late life.
Roxanna Korologou-LindenBing XuElizabeth CoulthardEsther WaltonAlfie R WearnGibran HemaniTonya WhiteCharlotte CecilTamsin SharpHenning TiemeierTobias BanaschewskiArun L W BokdeSylvane DesrivièresHerta FlorAntoine GrigisHugh GaravanPenny GowlandAndreas HeinzRüdiger BrühlJean-Luc MartinotMarie-Laure Paillère MartinotEric ArtigesFrauke NeesDimitri Papadopoulos OrfanosTomáš PausLuise PoustkaSabina MillenetJuliane H FröhnerMichael SmolkaHenrik WalterJeanne WintererRobert WhelanGunter SchumannLaura D HoweYoav Ben-ShlomoNeil M DaviesEmma Louise AndersonPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
Genetic liability to AD is likely to affect risk of AD primarily through mechanisms affecting indicators of brain morphology in later life, rather than structural brain reserve. Future studies with repeated measures are required for a better understanding and certainty of the mechanisms at play.