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Impact of add-back FSH on human and mouse prostate following gonadotropin ablation by GnRH antagonist treatment.

Eleftherios E DeiktakisEleftheria IeronymakiPeter ZarénAgnes HagsundElin WirestrandJohan MalmChristos TsatsanisIlpo T HuhtaniemiAleksander GiwercmanYvonne Lundberg Giwercman
Published in: Endocrine connections (2022)
These data provide novel evidence for the direct effects of FSH on prostate size and gene expression in chemically castrated mice. However, in chemically castrated men, FSH had no effect on PSA production. Whether FSH effects on the prostate in humans also require suppression of the residual adrenal-derived androgens and/or a longer period of rFSH stimulation, remains to be explored.
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