Impact of add-back FSH on human and mouse prostate following gonadotropin ablation by GnRH antagonist treatment.
Eleftherios E DeiktakisEleftheria IeronymakiPeter ZarénAgnes HagsundElin WirestrandJohan MalmChristos TsatsanisIlpo T HuhtaniemiAleksander GiwercmanYvonne Lundberg GiwercmanPublished in: Endocrine connections (2022)
These data provide novel evidence for the direct effects of FSH on prostate size and gene expression in chemically castrated mice. However, in chemically castrated men, FSH had no effect on PSA production. Whether FSH effects on the prostate in humans also require suppression of the residual adrenal-derived androgens and/or a longer period of rFSH stimulation, remains to be explored.
Keyphrases
- prostate cancer
- gene expression
- benign prostatic hyperplasia
- radical prostatectomy
- endothelial cells
- dna methylation
- electronic health record
- induced pluripotent stem cells
- type diabetes
- high fat diet induced
- metabolic syndrome
- big data
- middle aged
- machine learning
- skeletal muscle
- atrial fibrillation
- radiofrequency ablation
- catheter ablation