Th17/1 and ex-Th17 cells are detected in patients with polyarticular juvenile arthritis and increase following treatment.
Stephanie WoodJustin BranchPriscilla VasquezMarietta M DeGuzmanAmanda BrownAnna Carmela Sagcal-GironellaSaimun SinglaAndrea RamirezTiphanie P VogelPublished in: Pediatric rheumatology online journal (2024)
Patients with polyJIA have increased baseline Th17 cells, potentially reflecting higher tonic STAT3 activation in vivo. These quantifiable immune markers may identify patients that would benefit upfront from pathway-focused biologic therapies. Our data also suggest that inflammatory CD4 + T cell subsets not detected in controls but increased in post-treatment samples should be further evaluated as a tool to stratify patients in remission on medication. Future work will explore these proposed diagnostic and prognostic biomarkers.
Keyphrases
- end stage renal disease
- ejection fraction
- induced apoptosis
- newly diagnosed
- chronic kidney disease
- rheumatoid arthritis
- peritoneal dialysis
- prognostic factors
- healthcare
- cell cycle arrest
- oxidative stress
- emergency department
- cell death
- signaling pathway
- patient reported outcomes
- big data
- peripheral blood
- smoking cessation