Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages.

Pei-Chi ChenMiao-Hsi HsiehWen-Shuo KuoLawrence Shih-Hsin WuHui-Fang KaoLi-Fan LiuZhi-Gang LiuWen-Yih JengJiu-Yao Wang

Published in: Journal of biomedical science (2022)

We found a novel mechanism of moonlighting LGp40 in the reversal of M2-prompted Th2 cell activation through glycolytic activity, which has an important immunoregulatory role in preventing allergic asthma. Our results provide a new strategy for probiotics application in alleviating allergic asthma.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
lung function
single cell
cell therapy
cystic fibrosis
air pollution
mesenchymal stem cells