Examination of the ovotoxicity of 5-fluorouracil in mice.
M LambourasS H LiewK HorvayH E AbudJ M StringerKarla J HuttPublished in: Journal of assisted reproduction and genetics (2018)
These findings suggest that a single dose of 5-FU is mildly ovotoxic, but any effects on ovarian function are likely transient because the primordial follicle population is not depleted. Collectively, these data support the notion that 5-FU is unlikely to impact on the long-term fertility of women.