Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures.
Umair MahmoodAndrew BlakeSanjay RatheeLeslie M SamuelGraeme I MurrayDavid Sebag-MontefioreSimon GollinsNicholas P WestRubina BegumSimon P BachSusan D RichmanPhilip QuirkeKeara L RedmondManuel Salto TellezViktor Hendrik KoelzerSimon J LeedhamIan P M TomlinsonPhilip David DunneFrancesca M Buffanull nullTimothy S MaughanEnric DomingoPublished in: Cancer research communications (2024)
Rectal cancers with stromal features may respond better to RT and 5FU/Cap with the addition of Ox. Within patients not treated with Ox, high levels of cytotoxic lymphocytes associate with response only in immune and stromal tumors. Our analyses provide biological insights about the outcome by different radiotherapy regimens in rectal cancer.
Keyphrases
- rectal cancer
- locally advanced
- end stage renal disease
- early stage
- bone marrow
- newly diagnosed
- radiation therapy
- chronic kidney disease
- squamous cell carcinoma
- ejection fraction
- gene expression
- prognostic factors
- radiation induced
- lymph node
- peritoneal dialysis
- genome wide
- patient reported outcomes
- dna methylation
- low density lipoprotein