Genome-wide association studies and genomic prediction of breeding values for calving performance and body conformation traits in Holstein cattle.

Mohammed K Abo-IsmailLuiz F BritoStephen P MillerMehdi SargolzaeiDaniela A GrossiSteve S MooreGraham PlastowPaul StothardShadi NayeriFlavio S Schenkel

Published in: Genetics, selection, evolution : GSE (2017)

Various SNPs that are significantly associated with calving performance are located within or nearby genes with potential roles in tight junction, oxytocin signaling, and MAPK signaling. Combining the significant SNPs or SNPs within or nearby gene(s) from the HD panel with the BovineSNP50 panel yielded a marginal increase in the accuracy of prediction of genomic estimated breeding values for all traits compared to the use of the BovineSNP50 panel alone.

Keyphrases

genome wide
genome wide association
copy number
dna methylation
signaling pathway
oxidative stress
gene expression
heat stress
pi k akt
molecular dynamics simulations
human health
transcription factor