Metabolomics reveal alterations in arachidonic acid metabolism in Schistosoma mekongi after exposure to praziquantel.

Peerut Chienwichai Phornpimon Tipthara Joel TarningYanin LimpanontPhiraphol ChusongsangYupa ChusongsangPoom AdisakwattanaOnrapak Reamtong

Published in: PLoS neglected tropical diseases (2021)

Our findings suggest that arachidonic acid metabolism is a possible target in the parasiticidal effects of PZQ against S. mekongi. Identifying potential targets of the effective drug PZQ provides an interesting viewpoint for the discovery and development of new agents that could enhance the prevention and treatment of schistosomiasis.

Keyphrases

small molecule
mass spectrometry
genome wide
emergency department
high throughput
single cell
risk assessment
climate change
adverse drug
replacement therapy
drug induced