Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents.
Tobias C WoodDiana CashEilidh E MacNicolCamilla SimmonsEugene KimDavid J LythgoeFernando ZelayaFederico Edoardo TurkheimerPublished in: Wellcome open research (2021)
Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without an in-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO 2 ) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.
Keyphrases
- magnetic resonance imaging
- high resolution
- subarachnoid hemorrhage
- cerebral ischemia
- computed tomography
- pulmonary embolism
- metabolic syndrome
- blood pressure
- magnetic resonance
- white matter
- skeletal muscle
- photodynamic therapy
- single molecule
- room temperature
- mass spectrometry
- diffusion weighted imaging
- blood brain barrier
- atomic force microscopy
- ionic liquid
- glycemic control