CTLA-4 Blockade of Natural Killer Cells Increases Cytotoxicity against Acute Lymphoid Leukaemia Cells Neda.

Neda Parvini Mohammad Esmaeil AkbariAmir Ali HamidiehFardin FathiAbbas Ali AminiMarzieh Ebrahimi Zakaria Vahabzadeh

Published in: Cell journal (2024)

Our findings suggest that CTLA-4 blockage of Nalm-6 cells causes an increase in antitumour activity of NK cells against these cells. Our study also provides evidence for the potential of cancer immunotherapy treatment using blocking anti-CTLA-4 mAbs.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
natural killer cells
oxidative stress
cell death
nk cells
liver failure
intensive care unit
risk assessment
respiratory failure
extracorporeal membrane oxygenation