Rare case of Ureaplasma parvum septic arthritis in an immunocompetent patient.
Abuzar Ali AsifMoni RoySharjeel AhmadPublished in: BMJ case reports (2020)
Mycoplasmatacea family comprises two genera: Mycoplasma and Ureaplasma Ureaplasma parvum (previously known as U. urealyticum biovar 1) commonly colonises the urogenital tract in humans. Although Ureaplasma species have well-established pathogenicity in urogenital infections, its involvement in septic arthritis has been limited to prosthetic joint infections and immunocompromised individuals. We present a rare case of native right knee infection due to U. parvum identified using next-generation sequencing of microbial cell-free DNA testing and confirmed with PCR assays. This rare case of Ureaplasma septic arthritis was diagnosed using newer next-generation DNA sequencing diagnostic modalities and a literature review of prior cases, antibiotic coverage and antimicrobial resistance is incorporated as part of the discussion.
Keyphrases
- rare case
- antimicrobial resistance
- rheumatoid arthritis
- acute kidney injury
- case report
- circulating tumor
- total knee arthroplasty
- microbial community
- knee osteoarthritis
- high throughput
- single molecule
- copy number
- cystic fibrosis
- pseudomonas aeruginosa
- cell free
- gene expression
- biofilm formation
- staphylococcus aureus
- dna methylation
- genetic diversity
- health insurance