Characterization of the colonic response to bisacodyl in children with treatment-refractory constipation.
Paul T HeitmannLukasz WiklendtNikhil ThaparOsvaldo BorrelliCarlo Di LorenzoDesalegn T YacobDesiree F BaalemanMana H VriesmanSamuel NurkoKhalil El-ChammasAjay KaulMarc A BenningaIlan J N KoppenDavid A WattchowSimon J H BrookesPhil G DinningPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)
Intraluminal bisacodyl induced HAPCs in 93% of children with treatment-refractory constipation. The bisacodyl response is characterized by ≥1 HAPC within 12 minutes of infusion. The majority of HAPCs terminate in a synchronous pressurization in the rectosigmoid. Optimal clinical management based upon colonic manometry findings is yet to be determined.