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Characteristics and mechanisms of T-cell senescence: A potential target for cancer immunotherapy.

Han WuJunru LiZhen ZhangYi Zhang
Published in: European journal of immunology (2024)
Immunosenescence, the aging of the immune system, leads to functional deficiencies, particularly in T cells, which undergo significant changes. While numerous studies have investigated age-related T-cell phenotypes in healthy aging, senescent T cells have also been observed in younger populations during pathological conditions like cancer. This review summarizes the recent advancements in age-associated alterations and markers of T cells, mechanisms, and the relationship between senescent T cells and the tumor microenvironment. We also discuss potential strategies for targeting senescent T cells to prevent age-related diseases and enhance tumor immunotherapy efficacy.
Keyphrases
  • papillary thyroid
  • dna damage
  • endothelial cells
  • cancer therapy
  • squamous cell carcinoma
  • squamous cell
  • young adults
  • atomic force microscopy
  • risk assessment
  • high resolution
  • case control
  • childhood cancer