Intratumoral CXCL13+CD8+T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma.
Siyuan DaiHan ZengZhaopei LiuKaifeng JinWenbin JiangZewei WangZhiyuan LinYing XiongJiajun WangYuan ChangQi BaiYu XiaLi LiuYu ZhuLe XuYang QuJianming GuoJiejie XuPublished in: Journal for immunotherapy of cancer (2022)
Intratumoral CXCL13+CD8+T cells infiltration indicated inferior clinical outcome in patients with ccRCC. CXCL13+CD8+T cells possessed increased exhausted markers, decreased effector molecules and better proliferation ability. CXCL13+CD8+T cells abundance impaired total CD8+T cells' immune function. Intratumoral CXCL13+CD8+T cells abundance was associated with immunoevasive contexture. The abundance of CXCL13+CD8+T cells was an independent prognosticator and a potential immunotherapeutic target marker for ccRCC treatment.