Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging.
Qing WangSuzanne E SchindlerGengsheng ChenNicole S McKayAustin McCulloughShaney FloresJingxia LiuZhexian SunSicheng WangWenshang WangJason HassenstabCruchaga CarlosRichard J PerrinAnne M FaganJohn C MorrisYong WangTammie L S BenzingerPublished in: Neurology (2024)
Those findings suggest that WM neuroinflammation undergoes alterations before the onset of AD clinical symptoms and that it interacts with amyloidosis. This highlights the potential value of noninvasive monitoring of WM neuroinflammation in AD progression and treatment.
Keyphrases
- lipopolysaccharide induced
- lps induced
- traumatic brain injury
- cognitive impairment
- white matter
- cerebral ischemia
- inflammatory response
- high resolution
- mild cognitive impairment
- subarachnoid hemorrhage
- physical activity
- risk assessment
- combination therapy
- multiple myeloma
- mass spectrometry
- binding protein
- sleep quality