Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices.

Asmaa M Zahran Helal F HettaZeinab Albadry M ZahranAlaa RashadAmal RayanDalia O MohamedZeinab Ahmed Abd ElhameedSalah M KhallafGaber El-Saber BatihaYasir Waheed Khalid MuhammadHanaa Nafady-Hego

Published in: Journal of immunology research (2021)

Mo-MDSCs represent one of the key mechanisms in the immunosuppressive tumor microenvironment (TME) to play major roles not only in the carcinogenesis of lung cancer but also in disease progression and prognosis and, in addition, predict the efficacy of immune checkpoint inhibitors; our results provided some support to target Mo-MDSCs and needed to be augmented by further studies.

Keyphrases

advanced non small cell lung cancer
epidermal growth factor receptor
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
tyrosine kinase