Epigenetic evidence of an Ac/Dc axis by VPA and SAHA.

Sebastian Lunke Scott Maxwell Ishant Khurana Harikrishnan Kaipananickal Jun Okabe Keith Al-Hasani Assam El-Osta

Published in: Clinical epigenetics (2021)

The results provide an important framework for understanding the Ac/Dc axis by highlighting a broader complexity of histone modifications by the most established and efficacious anti-epileptic medication in this class, VPA and comparison with the broad spectrum HDAC inhibitor, SAHA.

Keyphrases

histone deacetylase
dna methylation
dendritic cells
gene expression
healthcare
emergency department
adverse drug
clinical evaluation