Bona fide dendritic cells are pivotal precursors for osteoclasts.

Antonia Puchner Elisabeth SimaderVictoria SaferdingMelanie HofmannMarkus KielerJulia BrunnerRené PfeifleBirgit NiederreiterGerhard KrönkeGernot SchabbauerPhilippe GeorgelGretchen DiehlGuenter SteinerSilvia HayerKurt RedlichJosef S SmolenDaniel Aletaha Stephan Blüml

Published in: Annals of the rheumatic diseases (2023)

Taken together, we identify DCs as important OC precursors in bone homeostasis and inflammation, which might open new avenues for therapeutic interventions in OC-mediated diseases.

Keyphrases

dendritic cells
bone loss
oxidative stress
immune response
minimally invasive
bone mineral density
regulatory t cells
physical activity
soft tissue
body composition
postmenopausal women