A new prenylated coumarin and a new anthranilamide derivative from Evodia lepta.

Xing-Lin XieGuo-Hua YeJun-Juan XueTong SuGui-Hua TangWei LiSheng Yin

Published in: Journal of Asian natural products research (2019)

A new prenylated coumarin (1) and a new anthranilamide derivative (2) were isolated from the aerial parts of Evodia lepta. Compound 2 represents the first anthranilamide derivative from the Evodia genus. Their structures were elucidated by spectroscopic data analysis (MS, UV, IR, and NMR). Compound 1 exhibited certain inhibition on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophages with an IC50 value of 37.96 ± 1.7 μM.

Keyphrases

data analysis
nitric oxide
inflammatory response
high resolution
fluorescent probe
water soluble
mass spectrometry
magnetic resonance
multiple sclerosis
molecular docking
toll like receptor
hydrogen peroxide
lps induced
anti inflammatory
solid state
molecular dynamics simulations
aqueous solution