Relationship between metabolic phenotypes and genotypes of CYP1A2 and CYP2A6 in the Nigerian population.
Ayorinde AdehinOluseye Oladotun BolajiSimran MaggoMartin A KennedyPublished in: Drug metabolism and personalized therapy (2017)
Our findings suggest that CYP1A2 alleles or haplotypes were not predictive of metabolic phenotypes in the Nigerian population. Carriers of CYP2A6*9/*17 genotype are likely to be poor metabolisers of CYP2A6 substrates and may experience adverse reactions or poor efficacy while using drugs metabolised mainly by CYP2A6.
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