Circulating ceramide ratios and risk of vascular brain aging and dementia.

Emer R McGrathJayandra J HimaliVanessa XanthakisMeredith S DuncanJean E SchafferDaniel S OryLinda R PetersonCharles DeCarliMatthew P PaseClaudia L SatizabalRamachandran S VasanAlexa S BeiserSudha Seshadri

Published in: Annals of clinical and translational neurology (2020)

Higher plasma ratios of very long-chain to long-chain ceramides are associated with a reduced risk of incident dementia and AD dementia in our community-based sample. Circulating ceramide ratios may serve as potential biomarkers for predicting dementia risk in cognitively healthy adults.

Keyphrases

mild cognitive impairment
cognitive impairment
cognitive decline
cardiovascular disease
type diabetes
white matter
multiple sclerosis