Palmitoylation is required for TNF-R1 signaling.

Philipp ZinglerVinzenz SärchenTimo GlatterLotta CaningCarina SaggauRahul S KathayatBryan C DickinsonDieter AdamWulf Schneider-BrachertStefan SchützeJürgen Fritsch

Published in: Cell communication and signaling : CCS (2019)

Our results introduce palmitoylation as a new layer of dynamic regulation of TNF-R1 induced signal transduction at a very early step of the TNF induced signaling cascade. Understanding the underlying mechanism may allow novel therapeutic options for disease treatment in future.

Keyphrases

rheumatoid arthritis
high glucose
diabetic rats
drug induced
endothelial cells
stress induced