Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.
Melody ChemalyDavid MarleviMaría Jesús IglesiasMariette LengquistMalin KronqvistDaniel BosDianne H K van Dam-NolenAnja Gwendolyn van der KolkJeroen HendrikseMohamed KassemLjubica MaticJacob OdebergMargreet R de VriesMarianne Eline KooiUlf HedinPublished in: Biomolecules (2023)
Plasma BLVRB was associated with IPH and increased risk of recurrent ischemic stroke in patients with symptomatic low- to moderate-grade carotid stenosis, indicating the capacity to monitor the efficacy of IPH-preventive pharmacotherapy in an animal model. Together, these results suggest the utility of plasma BLVRB as a biomarker for atherosclerotic plaque instability.