Dual Effect of Histidine on Polysorbate 20 Stability: Mechanistic Studies.

Lin ZhangSandeep YadavY John WangOlivier MozziconacciChristian Schöneich

Published in: Pharmaceutical research (2018)

L-His exhibits a dual effect on the stability profile of PS20, protecting against AAPH-induced oxidation but promoting oxidative degradation during accelerated stability testing.

Keyphrases

high glucose
diabetic rats
hydrogen peroxide
oxidative stress
drug induced