Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis.

Giuseppe Pontillo Maria Petracca Serena Monti Mario Quarantelli Chiara Criscuolo Roberta Lanzillo Enrico Tedeschi Andrea Elefante Vincenzo Brescia Morra Arturo Brunetti Sirio Cocozza Giuseppe Palma

Published in: AJNR. American journal of neuroradiology (2021)

Quantitative MRI suggests an atrophy-related iron increase within the basal ganglia of patients with MS, along with an atrophy-independent reduction of thalamic iron and myelin correlating with disability. Absolute depletions of thalamic iron and myelin may represent sensitive markers of subcortical GM damage, which add to the clinical impact of thalamic atrophy in MS.

Keyphrases

multiple sclerosis
white matter
deep brain stimulation
iron deficiency
mass spectrometry
ms ms
magnetic resonance imaging
high resolution
oxidative stress