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Ductal and acinar components of mixed prostatic adenocarcinoma frequently have a common clonal origin.

Claes LindhHemamali SamaratungaBrett DelahuntRebecka BergströmVenkatesh ChellappaJohn YaxleyJohan LindbergLars Egevad
Published in: The Prostate (2022)
Ductal and acinar prostate adenocarcinoma components of mixed tumors most often share the same origin and are clonally related. DA components in mixed tumor often exhibit genome doubling events resulting in aneuploidy, consistent with the aggressive nature of high grade prostate cancer.
Keyphrases
  • prostate cancer
  • high grade
  • radical prostatectomy
  • squamous cell carcinoma
  • benign prostatic hyperplasia
  • locally advanced
  • low grade
  • genome wide
  • radiation therapy
  • dna methylation