Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study.

Ruben D HouvastVictor M BaartShadhvi S BhairosinghRobert A CordfunkeJia Xin ChuaMireille VankemmelbekeTina ParsonsPeter J K KuppenLindy G DurrantAlexander L VahrmeijerCornelis F M Sier

Published in: Molecular imaging and biology (2020)

Using a novel chimeric Lewisa/c/x-targeting tracer in combination with a clinical NIRF imager, we demonstrate the potential of targeting Lewis glycans for fluorescence-guided surgery of gastrointestinal tumors.

Keyphrases

cell therapy
cancer therapy
minimally invasive
high resolution
cell surface
quantum dots
single molecule
living cells
stem cells
positron emission tomography
pet imaging
computed tomography
mass spectrometry
acute coronary syndrome
label free
fluorescent probe