Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study.
Marina A BykanovaMaria A SolodilovaIuliia E AzarovaElena Y KlyosovaOlga Y BushuevaAnna A PolonikovaMikhail I ChurnosovAlexey V PolonikovPublished in: Molecular biology reports (2022)
The present study was the first to show that genetic variation at the catalytic subunit of glutamate-cysteine ligase may contribute to the risk of colorectal cancer risk. However, further genetic association studies with a larger sample size are required to substantiate the role of GCLC gene polymorphisms in the development of sporadic colorectal cancer.