Target Attainment and Population Pharmacokinetics of Nirmatrelvir/Ritonavir in Critically Ill Adult Patients.

Na ChenXuben YuLu LiPing YangRong DongYizhen HuangXiao LingQiaoqiao ShentuWenqiao YuSaiping Jiang

Published in: Infection and drug resistance (2024)

Based on our dosing simulations, the initial dosage of NIR/RIT was 300mg/100mg twice a day in critically ill patients with CrCL>45 mL/min; When CrCL in critically ill patients is between 15 and 45 mL/min, NIR/RIT is 150mg/100mg twice a day. The maintenance dose is adjusted according to CrCL and AUC of RIT, with the dosages varying between 75mg/100mg and 300mg/100mg.

Keyphrases

photodynamic therapy
drug delivery
fluorescent probe
antiretroviral therapy