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Osteoporosis treatment with risedronate: a population pharmacokinetic model for the description of its absorption and low plasma levels.

B CardozoE KaratzaVangelis D Karalis
Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2021)
The absorption and disposition kinetics of risedronate were successfully characterized. Simulations revealed the high discrepancy in the concentration levels observed after different dosage regimens, implying the safety profile of risedronate. In virtual patients with renal impairment, the blood levels of risedronate are increased, but not in an extent requiring dose adaptation.
Keyphrases
  • bone mineral density
  • single cell
  • body composition