Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma.
Lu TianLuqing ZhaoKaren Man-Fong SzeCharles Shing KamVanessa Sheung-In MingXia WangVanilla Xin ZhangDaniel Wai-Hung HoTan-To CheungLo-Kong ChanIrene Oi Lin NgPublished in: Hepatology (Baltimore, Md.) (2021)
Our results provide new biological insight that dysregulation of RalA signaling through dual regulatory mechanisms supports its oncogenic functions in HCC. Targeting RalA may serve as a potential alternative therapeutic approach alone or in combination with currently available therapy.