Advancements in Three Dimensional In-Vitro Cell Culture Models.

The scientific field is observing a gradual shift from monolayer cultures to three-dimensional (3D) models, as they give a more relevant data in pre-clinical stages. This review summarizes the major techniques and materials used to develop 3D platforms, especially for cancer. It also discusses the challenges and some unresolved issues of the field and highlights some techniques that have made it to the market.