Differential red blood cell age fractionation and Band 3 phosphorylation distinguish two different subtypes of warm autoimmune hemolytic anemia.
Evgenia M BlochHaley A BranchDarinka SakacRegina M LegerDonald R BranchPublished in: Transfusion (2020)
Type I patients have increased Band 3 tyrosine phosphorylation that may represent accelerated aging of their RBCs resulting in exacerbation of a pathologic form of RBC senescence. Type II patients show decreased Band 3 tyrosine phosphorylation and lack the oldest, most dense RBCs suggesting premature RBC clearance and a more severe wAIHA.
Keyphrases
- end stage renal disease
- red blood cell
- chronic kidney disease
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- chronic obstructive pulmonary disease
- squamous cell carcinoma
- dna damage
- protein kinase
- multiple sclerosis
- early onset
- radiation therapy
- patient reported outcomes
- neoadjuvant chemotherapy
- lymph node
- patient reported
- extracorporeal membrane oxygenation
- locally advanced