Maternal separation affects the electrophysiological properties of Aδ-fibres and nociceptive behaviours in male and female mice.
Nancy PaniaguaRocío GirónCarlos Goicoechea GarcíaMª Isabel Martín-FontellesAna BaguesPublished in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2020)
Although MS increases the activity and the mechanosensitivity of cutaneous Aδ-afferent fibres at both short and long periods of separation, only the longer interval of time induces nociceptive sensitivity alterations during adulthood. These results highlight the possible influence of a stress free environment during childhood to reduce nociceptive alterations in adulthood.
Keyphrases
- neuropathic pain
- early life
- liquid chromatography
- depressive symptoms
- mass spectrometry
- multiple sclerosis
- spinal cord
- spinal cord injury
- ms ms
- birth weight
- type diabetes
- high fat diet induced
- pregnancy outcomes
- body mass index
- weight loss
- heat stress
- adipose tissue
- childhood cancer
- wild type
- gestational age
- preterm birth