The Impact of Germline Alterations in Appendiceal Adenocarcinoma.

Michael B Foote Henry S Walch Yelena M Kemel Efsevia Vakiani Paul Johannet Margaret Sheehan Walid K Chatila Sebastian K Chung Garrett M Nash Anna Maio Jinru Shia Diana L Mandelker Michael F Berger Nikolaus Schultz Luis A Diaz Andrea Cercek Zsofia K Stadler

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Germline variants are likely incidental without a contributory driver role in appendiceal adenocarcinoma. Appendiceal adenocarcinoma screening in patients with germline variants is not clearly merited.

Keyphrases

low grade
squamous cell carcinoma
dna repair
locally advanced
copy number
high grade
rectal cancer
gene expression
genome wide