Alcohol-Induced Behaviors Require a Subset of Drosophila JmjC-Domain Histone Demethylases in the Nervous System.

Jorge H PinzónAddison R ReedNevine A ShalabyMichael BuszczakAylin R RodanAdrian Rothenfluh

Published in: Alcoholism, clinical and experimental research (2017)

Our study reveals that the Drosophila JmjC-domain histone demethylases Lid, KDM3, NO66, and HSPBAP1 are required for normal EtOH-induced sedation and tolerance. Three of 3 tested of those 4 JmjC genes are required in the nervous system for normal alcohol-induced behavioral responses, suggesting that this gene family is an intriguing avenue for future research.

Keyphrases

genome wide analysis
high glucose
diabetic rats
dna methylation
drug induced
oxidative stress
gene expression
transcription factor
genome wide