Circulating extracellular vesicles induce monocyte dysfunction and are associated with sepsis and high mortality in cirrhosis.

Sukriti Baweja Chaggan BihariPreeti NegiSwati ThangariyalAnupma KumariDeepika LalDeepanshu MaheshwariJaswinder Singh MarasNidhi NautiyalGuresh KumarAnupam KumarNirupama TrehanpatiGautam MehtaAshok Kumar ChaudharyRakhi MaiwallShiv Kumar Sarin

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

Extracellular vesicles induce functional impairment in circulating monocytes and contribute to the development and perpetuation of sepsis. High levels of monocyte EV correlate with mortality and can help early stratification of sicker patients.

Keyphrases

dendritic cells
end stage renal disease
cardiovascular events
acute kidney injury
intensive care unit
newly diagnosed
ejection fraction
septic shock
endothelial cells
risk factors
peritoneal dialysis
prognostic factors
oxidative stress
patient reported outcomes