Evaluation of next-generation sequencing-based clonality analysis of T-cell receptor gamma gene rearrangements based on a new interpretation algorithm.

Friedel NolletKarlien VanhouteghemStefanie VermeireEllen MaelbranckeJan EmmerechtsHelena DevosBarbara Cauwelier

Published in: International journal of laboratory hematology (2018)

Assessment of T-cell clonality by TRG NGS has a significant added value in the diagnosis of T-cell disorders as an adjunct to PCR-CE, particularly in difficult to interpret cases or when analyzing FFPE samples.

Keyphrases

copy number
machine learning
genome wide
deep learning
genome wide identification
circulating tumor
dna methylation
neural network
energy transfer
gene expression
real time pcr
cell free
clinical evaluation