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Evaluation of next-generation sequencing-based clonality analysis of T-cell receptor gamma gene rearrangements based on a new interpretation algorithm.

Friedel NolletKarlien VanhouteghemStefanie VermeireEllen MaelbranckeJan EmmerechtsHelena DevosBarbara Cauwelier
Published in: International journal of laboratory hematology (2018)
Assessment of T-cell clonality by TRG NGS has a significant added value in the diagnosis of T-cell disorders as an adjunct to PCR-CE, particularly in difficult to interpret cases or when analyzing FFPE samples.
Keyphrases
  • copy number
  • machine learning
  • genome wide
  • deep learning
  • genome wide identification
  • circulating tumor
  • dna methylation
  • neural network
  • energy transfer
  • gene expression
  • real time pcr
  • cell free
  • clinical evaluation