Evaluation of next-generation sequencing-based clonality analysis of T-cell receptor gamma gene rearrangements based on a new interpretation algorithm.
Friedel NolletKarlien VanhouteghemStefanie VermeireEllen MaelbranckeJan EmmerechtsHelena DevosBarbara CauwelierPublished in: International journal of laboratory hematology (2018)
Assessment of T-cell clonality by TRG NGS has a significant added value in the diagnosis of T-cell disorders as an adjunct to PCR-CE, particularly in difficult to interpret cases or when analyzing FFPE samples.