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Cytochrome P450 oxidoreductase, POR, associated with severe paclitaxel-induced peripheral neuropathy in patients of European ancestry from ECOG-ACRIN E5103.

Fei ShenGuanglong JiangSantosh PhilipsLaura GardnerGloria R XueErica L CantorReynold C LyWilberforce OseiXi WuChau T DangDonald W NorthfeltTodd C SkaarKathy D MillerGeorge W SledgeBryan Paul Schneider
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Rare variants in POR, predict an increased risk of severe TIPN in patients of European ancestry who receive paclitaxel.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • peritoneal dialysis
  • early onset
  • patient reported
  • oxidative stress
  • patient reported outcomes
  • drug induced
  • copy number