Cytochrome P450 oxidoreductase, POR, associated with severe paclitaxel-induced peripheral neuropathy in patients of European ancestry from ECOG-ACRIN E5103.
Fei ShenGuanglong JiangSantosh PhilipsLaura GardnerGloria R XueErica L CantorReynold C LyWilberforce OseiXi WuChau T DangDonald W NorthfeltTodd C SkaarKathy D MillerGeorge W SledgeBryan Paul SchneiderPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Rare variants in POR, predict an increased risk of severe TIPN in patients of European ancestry who receive paclitaxel.