The Cytotoxic and Anti-Migratory Properties of Caesalpinia sappan and Ficus septica, in Combination with Doxorubicin on 4T1 TNBC Cells with Nephroprotective Potential.

Sari HaryantiUmmi Maryam ZulfinIrfani Aura SalsabilaFebri WulandariEdy Meiyanto

Published in: Asian Pacific journal of cancer prevention : APJCP (2022)

In conclusion, ECS and EFS effectively enhanced the cytotoxic effect of doxorubicin and inhibit cell migration on 4T1 cells and these activities may correlate to the inhibitory effect of NF-κB activation. ECS and EFS also exhibit ROS suppressing effect on Vero cells that may be beneficent to reduce nephrotoxicity of chemotherapeutic treatment.

Keyphrases

induced apoptosis
cell migration
signaling pathway
cell cycle arrest
drug delivery
oxidative stress
endoplasmic reticulum stress
immune response
risk assessment
lps induced
reactive oxygen species
nuclear factor
human health