Significance of Myelin Oligodendrocyte Glycoprotein Antibodies in CSF: A Retrospective Multicenter Study.
Sara CartaÁlvaro Cobo CalvoThaís ArmangueAlbert SaizChristian LechnerKevin RostásyMarkus BreuMatthias BaumannRomana HöftbergerIlya AyzenbergCarolin SchwakeMaria SepúlvedaEugenia Martínez-HernándezGemma Olivé-CireraGeorgina ArrambideMar TintoreRaphael Bernard-ValnetRenaud A Du PasquierFabienne BrilotSudarshini RamanathanKathrin SchandaAlberto GajofattoSergio FerrariElia SechiEoin P FlanaganSean J PittockVyanka RedenbaughMarkus ReindlRomain MarignierSara MariottoPublished in: Neurology (2022)
Paired serum and CSF MOG-Abs positivity is common in MOGAD and is associated with a more severe clinical presentation. CSF only MOG-Abs positivity can occur in patients with a phenotype suggestive of MOGAD and is associated with a worse outcome. Taken together, these data suggest a clinical interest in assessing CSF MOG-Abs in patients with a phenotype suggestive of MOGAD, regardless of the MOG-Abs serostatus.