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Dissecting the genetic architecture of suicide attempt and repeated attempts in Korean patients with bipolar disorder using polygenic risk scores.

Dongbin LeeJi Hyun BaekKyooseob HaEun-Young ChoYujin ChoiSo-Yung YangJi Sun KimYunji ChoHong-Hee WonKyung Sue Hong
Published in: International journal of bipolar disorders (2022)
The PRS for SA derived from EUR data was generalized to SA in Korean patients with BD. The PRS for OCD seemed to affect repeated attempts. Genetic studies on suicide could benefit from focusing on specific psychiatric diagnoses and refined sub-phenotypes, as well as from utilizing multiple PRSs for related disorders.
Keyphrases
  • bipolar disorder
  • genome wide
  • major depressive disorder
  • copy number
  • mental health
  • obsessive compulsive disorder
  • electronic health record
  • big data
  • dna methylation
  • case control
  • deep learning
  • deep brain stimulation