Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study.

Todd A MianoSean HennessyWei YangThomas G DunnAriel R WeismanOluwatosin OniyideRoseline S AgyekumAlexandra P TurnerCaroline A G IttnerBrian J AndersonF Perry WilsonRaymond TownsendJohn P ReillyHeather M GianniniChristopher V CosgriffTiffanie K JonesNuala J MeyerMichael G S Shashaty

Published in: Intensive care medicine (2022)

Vancomycin + piperacillin-tazobactam was associated with creatinine-defined AKI, but not changes in alternative kidney biomarkers, dialysis, or mortality, supporting the hypothesis that vancomycin + piperacillin-tazobactam effects on creatinine represent pseudotoxicity.

Keyphrases

methicillin resistant staphylococcus aureus
uric acid
gram negative
chronic kidney disease
acute kidney injury
cardiovascular events
staphylococcus aureus
end stage renal disease
metabolic syndrome
risk factors
coronary artery disease
peritoneal dialysis