Influence of genomic ancestry and self-reported color-race in CKD in a nationwide admixed sample of Brazilian patients with type 1 diabetes.
Marcela Haas PizarroDeborah Conte SantosLaura Gomes Nunes MeloBianca Senger Vasconcelos BarrosLuiza Harcar MunizLuís Cristóvão Moraes Sobrino PortoDayse Aparecida SilvaMarília Brito GomesPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2019)
In our patients, from an admixed, multi-ethnic population, we did not find an association between self-reported color-race, genomic ancestry and CKD. It is important to note that despite the fact that we did not find a significant p-value in the multivariate analysis concerning African ancestry and CKD, we found a narrow confidence interval (0.961-3.98) with an OR of 1.956. Further studies should be conducted to confirm the lack of association between African ancestry and CKD, especially from populations with higher African or Amerindian ancestries to better understand the association between self-reported color-race and genomic ancestry with CKD.