The B1 H + -ATPase ( Atp6v1b1 ) Subunit in Non-Type-A Intercalated Cells is Required for Driving Pendrin Activity and the Renal Defence Against Alkalosis.

Soline BourgeoisJana KovacikovaMilica Bugarski Carla BettoniNicole GehringAndrew M Hall Carsten Alexander Wagner

Published in: Journal of the American Society of Nephrology : JASN (2023)

Our data demonstrate a critical role of H + -ATPases in non-type-A IC function protecting against alkalosis and reveal a hitherto unrecognized need of basolateral B1 isoform for a proper H + -ATPase complexes assembly and ability to be stimulated.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum
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oxidative stress
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