Hypoxic 3D in vitro culture models reveal distinct resistance processes to TKIs in renal cancer cells.
Zofia Felicja BieleckaAgata MalinowskaKlaudia K BrodaczewskaAleksandra KlembaClaudine KiedaPaweł KrasowskiElżbieta GrzesiukJan PiwowarskiAnna M CzarneckaCezary SzczylikPublished in: Cell & bioscience (2017)
The results confirm that low oxygen tension affects RCC cells. Hypoxia facilitates induction of sorafenib resistance in pRCC and induces map2k1 overexpression, while normoxic axitinib-resistant cells up-regulated eif4b. Further studies may determine if map2k1 or eif4b proteins play a role in pRCC resistance to TKIs. It is also of interest to establish if other than vegfr-1, braf, c-kit receptors can serve as potential molecular targets for more effective anti-RCC strategies.