Posttraumatic stress disorder symptom severity is associated with reduced default mode network connectivity in individuals with elevated genetic risk for psychopathology.

Danielle R MillerMark W LogueErika J WolfHannah ManiatesMeghan E RobinsonJasmeet P HayesAnnjanette StoneSteven SchichmanRegina E McGlincheyWilliam P MilbergMark W Miller

Published in: Depression and anxiety (2017)

Findings illustrate the potential power of genome-wide PRSs to advance understanding of the relationship between PTSD and DMN connectivity, a putative neural endophenotype of the disorder.

Keyphrases

posttraumatic stress disorder
resting state
genome wide
functional connectivity
dna methylation
white matter
copy number
anorexia nervosa
patient reported